2 edition of Immunogentic and transplantation studies in the Rhesus monkey found in the catalog.
Immunogentic and transplantation studies in the Rhesus monkey
Arthur Anthon van Es
by Primate Center ofthe Organization for Health Research TNO in Rijswijk
Written in English
Jerry Silver, an expert in regrowing severed nerves, called White's experiments on monkeys, "fairly barbaric." During the s, White planned to perform the same operation on humans and practiced on corpses at a mortuary. It was hoped he could do head transplant surgery on the physicist Stephen Hawking and the actor Christopher Reeve. Chapter 8. The Importance of Monkeys for the Study of Malignant Tumors in Man Text References Chapter 9. The Use of Primates in Cardiovascular Research I. Introduction II. Historical Aspects of Primate Research III. The Selection of a Suitable Primate IV. The Rhesus Monkey V. The Baboon VI. The Squirrel Monkey VII. The Chimpanzee VIII.
In this chapter, I would like to introduce the first pediatric baboon-to-human heart transplantation and its basic animal experiments done by Bailey’s group and the following attempts for pediatric cardiac orthotopic xenotransplantation (rhesus monkey-to-baboon and pig-to-primate combination). We selected the optimum dose (Gy) to treat the corneal lamellae to be the grafts. The human grafts and fresh allogeneic monkey corneal lamellae were implanted into rhesus monkeys via the small incision femtosecond laser-assisted surgery, respectively. Clinical examinations and the immunostaining were performed after surgery.
OCLC Number: Description: 78 pages illustrations 26 cm. Contents: Introduction --Acknowledgments --Study areas --Subjects and definitions of terms --Methods --Results: Behavior of the original group before division, --Behavior during the period of trapping --Behavior of monkeys remaining on Cayo Santiago, --Behavior on Cayo Santiago, --Behavior of monkeys . To characterize the kinetics of natural CMV infection in rhesus macaques, quantification of CMV replication was performed in urine, saliva, and plasma specimens from eight 1-year-old, seven 2-year-old, nine 3-year-old, and 17 adult macaques (Figure 1A).Only a single 1-year-old monkey (12%) excreted virus in saliva, whereas all 2- and 3-year-old monkeys excreted CMV in their urine and saliva.
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Immunogenetic and Transplantation Studies in the Rhesus Monkey Paperback – January 1, by Drukkerij J.H. Pasmans Immunogentic and transplantation studies in the Rhesus monkey book See all formats and editions Hide other formats and editions.
Price New from Used from Paperback, January 1, "Please retry" — — $ Paperback from $ Author: Drukkerij J.H. Pasmans. Five alloimmune rhesus monkey blood typing reagents have been produced which define two new blood group loci inMacaca mulatto.
Three of these reagents detect blood group factors at theM locus; the other two detect factors at theN locus. By typing over pedigreed monkeys we have established that these two loci are independent of each other and of any of our previously defined blood group.
Rhesus monkey neural stem cells are capable of differentiating into neurons and glial cells. Therefore, neural stem cell transplantation can be used to promote functional recovery of the nervous system.
Rhesus monkey neural stem cells (1 × 10 5 cells/μL) were injected into bilateral hippocampi of rats with hippocampal lesions. Confocal laser Cited by: 1. A single recipient (R) that received a transplant with MHC-matched stem cells without immunosuppression (and who lived until day 26 after transplantation; Table 1) showed a striking, acute increase in serum bilirubin between days 23 and 26 after transplantation, with a serum bilirubin of μmol/L (23 mg/dL) (corresponding to stage IV Cited by: Immunogenetics: Date Published: Jul ISSN: Abstract: Indian rhesus macaque major histocompatibility complex (MHC) variation can influence the outcomes of transplantation and infectious disease studies.
Frequently, rhesus macaques are MHC genotyped to identify variants that could account for unexpected results. Nonhuman primates (NHP), primarily rhesus macaques (Macaca mulatta) and cynomolgus macaques (M. fascicularis), serve as important preclinical models for solid organ and hematopoietic stem cell transplantation by providing an essential link in the translation of mechanistic approaches developed in mice to successful clinical therapeutic strategies.
Although the central role. V, D, and J gene segments appear with unequal frequency in rhesus monkeys. The rhesus monkey has 64 V, 2 D and 13 J gene segments in germline references of the international ImMunoGeneTics information system (IMGT) database Each sequence read was assigned to a particular V, D and J by alignment to the germline referenWe identified 57 out of 64 V types.
To assay for transplacental immunization in rhesus monkeys, sera from postpartum females, 31 virgin females, and 40 males were tested for erythrocyte agglutinins. Nineteen percent of the mothers exhibited antibodies, but less than three percent of the virgin females or males did so.
Antibodies were detected in 26 percent of the mothers who bore blood group-incompatible infants, in contrast Cited by: 6. Nonhuman primate models are useful for studies on organ transplantation because of their relevance to clinical transplantation in humans. For example, genes that encode TCR and MHC proteins are well conserved between rhesus monkeys and humans [ As in humans, rhesus monkey endothelial cells express MHC class I and 11 molecules.
GBM thickening in spontaneously obese T2DM rhesus monkeys with diabetes duration comparable to the present study was previously shown by Cusumano et al. However, these authors found only a non-statistically significant trend toward mesangial expansion by subjective light microscopy assessment in diabetic monkeys [ 7 ], while we identified a.
The evidence for immune responsiveness genes in humans is still fragmentary, although the MHC includes Ir genes in several other species, for example, mouse, guinea pigs, rat, and rhesus monkey. This article discusses the detection of histocompatibility antigens in humans and how they are controlled by MHC genes.
Thus, in murine models of bone marrow transplantation (BMT), costimulation blockade–resistant rejection of donor BM was induced in the setting of virus-mediated memory T-cell expansion and heterologous immunity. 21 In addition, in both primate and clinical studies of solid-organ transplantation, significant rejection risks have been noted.
The Division of Immunogenetics and Transplantation Immunology in the Department of Medicine of the Johns Hopkins University School of Medicine is one of the premier Histocompatibility and Immunogenetics laboratories.
The laboratory was founded in by Dr. Wilma Bias and continued to grow under the leadership of Dr. Sue Leffell, Dr. Andrea. Two 4-year-old male rhesus monkeys (Macaca mulatta) were selected for porcine islet cell immunization and two 3-year-old monkeys were selected for porcine heart transplantation.
To maximize the length of organ survival in non-immunosuppressed non-human primates, all rhesus monkeys were chosen based on low xenoantibody levels specific for the. The donor cells for transplantation were recovered from the testicular parenchyma of two prepubertal rhesus monkeys using a two-step enzymatic digestion procedure in the Orwig lab at Magee Womens Research Institute (Hermann et al.,).
Cells were cryopreserved and shipped on. TransplantationRobinson PJ, Rowlands DT: Evidence of the alloimmunogenic potential of donor periodontal ligament. Am J PatholYeager JE, Riviere GR, Neefe JR, et al: Research on tooth transplantation in rhesus monkeys, in Riviere GR, Hildemann WH (eds): Oral Immunogenetics and Tissue Transplantation.
Transplantation of the monkey ES-derived neural cells brought about functional improvement of hemiplegic mice with experimental brain injury. There has been many publications presenting growth and differentiation of human ES cells in vitro (Amit and Itskovitz-Eldor,Carpenter et al.,Odorico et al.,Ostenfeld and Svendsen.
Among NHPs, old world monkeys are particularly valuable for use in neurological transplantation studies because they share critical neuroanatomical commonalities with humans, including physical separation of the nuclei of the striatum (Bove and Perier, ), which is the primary target of SNc neurons, and a gyrencephalic brain (Wu et al., ).
Rhesus monkey ESC lines R and R were maintained in the undifferentiated state by coculture with irradiated murine embryonic feeder cells.The culture conditions for optimal hematopoietic differentiation of these cells is illustrated in Fig.
rhesus ESC are grown on a layer of S17 mouse stromal cells, in IMDM medium supplemented with horse serum and fetal bovine serum.
The insulin-requiring T2D rhesus monkey is an excellent model for studies of islet transplantation and islet function. Such studies would have exciting potential to. The researchers implanted the chimeric embryos into five female rhesus monkeys, all of which became pregnant.
Tests on the foetuses confirmed that all of .AL r in the book “Characteristics, Detection, and Clinical Relevance of Alloantibodies in Kidney Transplantation”. Book Title “Kidney transplantation – New Perspectives”. ISBN Edited by: Dr.(Md) Magdalena Trzcinska. Publisher: InTech, August This makes transplantation difficult because it increases the risk of bleeding.
Such risk is further compounded when certain blood products are refused on religious grounds. We present a case of successful HLAi transplantation in a Jehovah's Witness across a positive-flow cytometric HLA crossmatch from a live donor who was also a Jehovah's Witness.